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Executive summary

1.1. Background

1.2. Rationale for the development of the 2022 consolidated guidelines

1.3. Objectives of the 2022 consolidated guidelines

1.4. Target audience

1.5. WHO recommendations relevant to the management of TB in children and adolescents

1.6. Scope of the guideline update

1.6.1. PICO questions

1.6.2. Background questions

1.7. Publication, dissemination, evaluation and expiry

1.8. Document structure

2. TB screening and contact investigation

3. Prevention of TB

4. Diagnostic approaches for TB in children and adolescents

4.1. The use of the Xpert MTB/RIF Ultra assay in gastric aspirate and stool specimens for the diagnosis of pulmonary TB and rifampicin resistance

4.1.1. Justification and evidence

4.1.2. Subgroup considerations

4.1.3. Implementation considerations

4.1.4. Monitoring and evaluation

4.2. Treatment decision algorithms for the diagnosis of pulmonary TB in children aged below 10 years of age