Screening

Screening

2.7 Systematic screening for TB disease among people attending health care services who have clinical risk factors for TB

7. In settings where the TB prevalence in the general population is 100/100 000 population or higher, systematic screening for TB disease may be conducted among people with a risk factor for TB who are either seeking health care or who are already in care

(existing recommendation: conditional recommendation, very low certainty of evidence).

8. People with an untreated fibrotic lesion seen on chest X-ray may be systematically screened for TB disease

2.2 Systematic screening for TB disease among people with structural risk factors for TB

2. Systematic screening for TB disease may be conducted among subpopulations with structural risk factors for TB. These include urban poor communities, homeless communities, communities in remote or isolated areas, indigenous populations, migrants, refugees, internally displaced persons and other vulnerable or marginalized groups with limited access to health care

(existing recommendation: conditional recommendation, very low certainty of evidence).

3.3.1.5 Molecular WHO-recommended rapid diagnostic tests for all other people living with HIV

The systematic review of the performance of an mWRD used to screen for TB among people living with HIV included 14 studies with a total of 9 209 participants (see Web Annex B, Table 16, and Web Annex C, Table 9). The Xpert MTB/RIF assay was the primary mWRD used in these studies. The prevalence of TB in the studies ranged from 1% to 26%.

3.3.1.3 Chest radiography

CXR is recommended by WHO to be used in parallel with the W4SS where CXR is available to assist in ruling out active TB prior to initiating TPT among people living with HIV who are on ART. The GDG agreed that, due to the increased sensitivity, the evidence supported using CXR in addition to the W4SS as a parallel screening strategy in which a positive or abnormal result on either screen would indicate a referral for diagnostic evaluation.