It is the responsibility of the laboratory manager to ensure that a biosafety management system is developed and adopted, as well as a safety or operations manual and a set of standard operating procedures.
The manager should ensure that staff are trained and their technical competence evaluated for performing different procedures.
Personnel should be advised of special hazards and be required to read the safety (or operations) manual as well as follow standard practices and procedures. The manager should make sure that all personnel have read the appropriate manuals and have signed a statement declaring that they have understood them. A copy of the most recent safety or operations manual, with its date of issue, should be available in the laboratory
Systems for heating, ventilation, air and containment (directional airflow) must have a permanent maintenance plan to ensure they always function properly.