4.3.3 Pulmonary TB

Pulmonary TB patients with radiological evidence of bilateral disease or radiological evidence of cavitation were included in the Nix-TB, ZeNix and TB-PRACTECAL studies. As such, patients with extensive pulmonary disease can be started on the BPaLM/BPaL regimen; however, close microbiological and clinical monitoring for culture conversion and clinical response should be maintained. In patients on the BPaL regimen, where there is a lack of culture conversion or clinical response between months 4 and 6, the regimen can be extended to 9 months (39 weeks) total duration.

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