Abbreviations

aDSM

active tuberculosis drug safety monitoring and management

AIDS

acquired immunodeficiency syndrome

aOR

adjusted odds ratio

ART

antiretroviral therapy

ARV

antiretroviral

BMI

body mass index

BPaL

a regimen of bedaquiline, pretomanid and linezolid

BPaLC

a regimen of bedaquiline, pretomanid, linezolid and clofazimine

BPaLM

a regimen of bedaquiline, pretomanid, linezolid and moxifloxacin

CB

clinical breakpoint

CC

critical concentration

CI

confidence interval

CNS

central nervous system

DRS

drug-resistance surveillance

DR-TB

drug-resistant tuberculosis

DST

drug susceptibility testing

ECG

electrocardiography

FDC

fixed-dose combination (of medicines)

GDF

Global Drug Facility

GDG

Guideline Development Group

GRADE

Grading of Recommendations Assessment, Development and Evaluation

HBV

hepatitis B virus

HCV

hepatitis C virus

HIV

human immunodeficiency virus

HR

isoniazid–rifampicin

HRZE

isoniazid–rifampicin–ethambutol–pyrazinamide

(H)RZE

(isoniazid optional)–rifampicin–ethambutol–pyrazinamide

Hr-TB

rifampicin-susceptible, isoniazid-resistant tuberculosis

IPD

individual patient data (or dataset)

IV

intravenous

LPA

line probe assay

MDR-TB

multidrug-resistant tuberculosis

MDR/RR-TB

multidrug- or rifampicin-resistant tuberculosis

MGIT

mycobacterial growth indicator tube

MIC

minimum inhibitory concentration

NAAT

nucleic acid amplification test

NTP

national tuberculosis programme

People with HIV

people living with HIV

pre-XDR-TB

pre-extensively drug-resistant tuberculosis

RCT

randomized controlled trial

rGLC

regional Green Light Committee

RR-TB

rifampicin-resistant tuberculosis

SoC

standard of care

TB

tuberculosis

TDM

therapeutic drug monitoring

WHO

World Health Organization

WHO/GTB

World Health Organization Global Tuberculosis Programme

XDR-TB

extensively drug-resistant tuberculosis

TB medicines

Am

amikacin

B or Bdq

bedaquiline

C or Cfz

clofazimine

Cs

cycloserine

Dlm

delamanid

E

ethambutol

Eto

ethionamide

H

isoniazid

Hh

isoniazid high dose

Ipm–Cln

imipenem–cilastatin

L or Lzd

linezolid

Lfx

levofloxacin

M or Mfx

moxifloxacin

Mpm

meropenem

P or Rpt

rifapentine

Pa

pretomanid

PAS

p-aminosalicylic acid

Pto

prothionamide

R

rifampicin

S

streptomycin

Z

pyrazinamide

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