As highlighted in Box 2.7, systematic screening for TB disease should be conducted among adolescents living with HIV using the WHO-recommended four-symptom screen (W4SS). Those who report any one of the symptoms of current cough, fever, weight loss or night sweats may have TB and should be evaluated for TB and other diseases. Adolescents living with HIV may also be screened using CRP (using a cut-off of >5 mg/L), CXR or mWRDs. Similar to adults, adolescents living with HIV who are inpatients in medical wards where TB prevalence is high (over 10%) should be tested systematically for TB disease with mWRDs (13). See Section 7.1 for more information on TB/HIV coinfection.