Book traversal links for 4.3. Formulation of the recommendations
GRADE evidence-to-decision frameworks were developed through the GRADEpro Guideline Development Tool (GDT) software to support the process of moving from evidence to decisions, help Guideline Development Groups structure their discussions, and make the process and the basis for decisions objective and transparent. In the context of global policies, the adoption of evidence-todecision frameworks facilitates the adaptation of recommendations and decisions to specific contexts, given that these frameworks take into account the prioritization of a public health condition, the balance of desirable and undesirable effects of a given intervention, and other domains such as values, resources, equity, acceptability and feasibility. For each priority question, judgements were made on the impact of the intervention on each domain, to inform and guide the decisionmaking process.