Children with severe acute malnutrition

No separate subgroup analysis could be conducted for children with SAM (defined as weight-forheight Z-score below −3 or mid-upper arm circumference below 115 mm (91)) in the SHINE trial due to the low numbers (30 children with SAM in the 16-week arm and 33 in the 24-week arm). As SAM is defined as a danger sign, even if children with SAM have a non-severe form of TB they should preferably receive 6 months of TB treatment.

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