6.2.4 Tests of TB infection

As for adults, tuberculin skin tests and interferon-g release assays should not be used to screen for TB disease in children (12, 34), as these tests cannot distinguish TB infection from TB disease and cannot predict who will progress to TB disease. Both tests may be influenced by mechanisms unrelated to TB infection and give false-negative or false-positive results. The role of these tests in decision-making for TPT is discussed elsewhere (4, 5).

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