2.4.2. Evidence on intervention effect

Five prospective cohort studies were identified, with a total of 7769 participants; four of the studies were newly identified. Three of the studies were conducted in South Africa and two in India (14–18). The studies included People with HIV, pregnant women, adolescents, health care workers and household contacts. The pooled risk ratio estimate for the TST was 1.49 (95% CI: 0.79– 2.80), and for IGRAs was 2.03 (95% CI: 1.18–3.50). Although the estimate for IGRAs was slightly higher than that for the TST, the 95% CIs for the estimates for the TST and IGRAs overlapped and were imprecise. Furthermore, there was limited evidence for the predictive utility of the tests in specific at-risk populations.

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