HIV-negative household and close contacts of a person with pulmonary TB: children and adolescents aged 5 years and over

Target groups for TPT were expanded from the 2018 WHO updated and consolidated guidelines for programmatic management (61) and later versions to include HIV-negative household contacts aged 5 years and over. In this target group, confirmation of TB infection using TST or IGRA, absence of any symptoms of TB, and absence of abnormal findings on CXR may be used to rule out TB disease before starting TPT (28).

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