3.3 Epidemiologic considerations

In selecting a diagnostic test to implement, it is important to consider the characteristics (i.e. risk factors) of the population being served. These characteristics should be derived from population-based studies, if available, and should include the proportion of:

  • TB cases resistant to RIF, INH and FQs;
  • PLHIV;
  • TB that is extrapulmonary;
  • TB among children;
  • those with severe illness requiring rapid diagnosis; and
  • people who are hospitalized versus those who are ambulatory.

Understanding the proportion resistant to a newly introduced drug (e.g. BDQ) is particularly important during the initial stages of using the drug, when treatment capacity may expand more rapidly than DST capacity.

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