There is a critical need for diagnostic tests with improved performance and predictive value for progression to active TB. In addition, the performance of TB infection tests should be evaluated in various risk groups, to assess reinfection and to understand how best to use available tools in each population (e.g. in combination, or sequential use of the TST and IGRAs).
Data synthesis was structured around the preset PICO question, as outlined above. See Web Annex H for additional information on evidence synthesis and analysis.