The successful implementation of this recommendation will depend upon the availability of more providers trained specifically in the care of HIV and DR-TB, and drug–drug interactions. A substantial increase in the availability of and patient’s access to treatment, and additional support for ensuring adherence would likely be needed. The need for increased integration of HIV and TB care for effective patient management, prompt evaluation of AEs and case-holding throughout treatment will necessitate more resources. For the benefit of the user, a table of AEs for which both an antiretroviral agent and an antituberculosis medicine have been implicated and could conceivably interact was included when these guidelines were published. Updated information on drug–drug interactions between antiretroviral and antituberculosis medicines is now available online (36).