Annex 3 Questions in population, intervention, control, outcomes (PICO) format

1. What is the optimal composition of the diet for patients receiving treatment for active TB?

a. Do patients who are newly diagnosed with TB have increased energy requirements?

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2. Should macronutrient supplements be recommended to improve TB treatment and health outcomes for well-nourished or undernourished patients being treated for active TB?

a. Does macronutrient supplementation, as food or high-energy supplements, improve TB treatment outcomes?

b. Does macronutrient supplementation, as food or high-energy supplements, improve nutritional recovery and quality of life?

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3. Should micronutrient supplements be recommended as a component of normal care in well-nourished or undernourished patients being treated for active TB for improving TB treatment and nutrition outcomes?

a. Does routine daily multi-micronutrient supplementation improve TB treatment outcomes

b. Does routine daily multi-micronutrient supplementation improve nutritional recovery and quality of life?

 

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4. Are there population-level nutritional interventions that could reduce the progression from latent to active TB in household contacts of patients with active TB?

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